Hepatitis C relapses are uncommon among those proclaimed cured

According to Reuters report, HCV patients achieve SVR 12 (sustained virologic response 12 weeks after completing treatment) and have minimal chances of a relapse. But there are a certain percentage of people who are at a risk of re-infection. Researchers conducted a systematic review and meta-analysis of studies involving 9,000 people with hep C and published their findings in Clinical Infectious Diseases.

They reviewed the information from 59 cases who reported post-hep C recurrence. This was classified into three groups:-

1) The low risk group of people who had showed no risk factors for reinfection as they tested negative for HIV
2) The high risk group, with individuals who had minimum one risk factor identified to cause reinfection such as use of injection drug
3) HIV/HCV co-infected persons

The low risk group had a post-SVR relapse rate of 0.82 per 1,000 person-years(the total years a participant spent in the study) with zero chances of reinfection.


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The reinfection rate among high risk group was around 19.06 per 1,000 person-years and no chances of last relapse. Prisoners reported the highest rate of reinfection at 45.48 per 1000 person-years.

The co-infected ones had a reinfection rate of 32.02 per 1,000 person years and a late relapse rate of zero.

In comprehensive terms, HCV recurrence was 0.95 for low risk group, 10.67 for high risk ones and 15.02 percent for the co-infected individuals.

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